My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Pregnancy. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. Definitely something to bring up. There are some options filled in, but you can also write in your own result. I'm sorry to hear that! to help the technology advance more with this newer test. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! Learn more about, Twins & Multiples: Your Tentative Time Table. The inconclusive result was due to my fetal fraction being 4.4%. You can do an amnio. Unlike most DNA, which is found inside a cell's . As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Update: my redraw came back low risk for everything! The waiting is almost unbearable. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. To complete all the standard tests which came back fine and were able to identify that it was a boy but again, suspect maternal abmormality involving X chromosomes. Yes. how to find the length of an oval track; how long to cook baked potato on grill; george pearsons house; distance from thunder bay to manitoba border Apparently some places will do your test when theyre not supposed to. Your body then filters it out. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. So frustrating!!! No, NIPT is a screening test, not a diagnostic test. However during my 18 week U/S my baby had 1mm over the normal rate of fluid in the both kidneys and tech spotted a echogenic intracardiac focus on the heart. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. That means whatever caused no result the first time is still interfering with the test. They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! The NIPT prenatal test is a trusted elective screening tool used to assess the genetic risk of a fetal chromosomal abnormality, such as Down syndrome, in the first trimester of pregnancy. What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. With my first daughter there was an ECF as well that resolved itself. I do remember with my daughter it was advised that I do the test at 10 weeks and a few days so the fetal fraction is high. It has to be at least above 4 percent to give a conclusive result. Getting my blood redrawn tomorrow. While it is not certain by any means, getting no result during a NIPT test might point toward an increased chance of chromosomal abnormalities. Keep us posted! I had both. The #1 app for tracking pregnancy and baby growth. Although I do have a very high BMI and am aware that this can cause inconclusive NIPT results too. . sm1232, did you get the results to your CVS? Surely I'm worried. In most cases, the results will say that a genetic condition is unlikely. The #1 app for tracking pregnancy and baby growth. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Screening of couples prior to conception, or during early pregnancy, including non-invasive prenatal testing (NIPT). 20052023 BabyCenter, LLC, a Ziff Davis company. It has to be at least above 4 percent to give a conclusive result. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward. Wouldn't that give you the results you're looking for? 20052023 BabyCenter, LLC, a Ziff Davis company. What to Expect has thousands of open discussions happening each day. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. To help you get started read our. I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. So doesnt seem like Im low risk but My obgyn wants to refer me to see a geneticist to discuss possible next steps. My nipt/panorama/harmony results came back inconclusive both times. Just got this email from the lab doing my test!!! This discussion is archived and locked for posting. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. hello, just wondering if this has happened to anyone? Find advice, support and good company (and some stuff just for fun). If you click on the green no results tag low FF youll find all the posts about this in the sub. Results in some cases may return inconclusive or uncertain. Just got my 2nd no result today. That means the results don't indicate for sure whether your baby has a chromosomal condition. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? Of course, this can be dispelled with subsequent retests. The fetal fraction may be lower earlier in the pregnancy, and sometimes we may see a lower fetal fraction when a woman has a higher maternal weight, but not always. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. When cells break down, they release . Patients having this testing should know that NIPT results do not diagnose a genetic condition or give a yes/no answer, and should seek follow-up testing if appropriate. Analysis of genes involved in drug metabolism and hypersensitivity, allowing clinicians to prescribe with confidence. It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Are you going to get retested? We are going to have an amnio in coming week as per the genetic councellor suggested us to see what is that coming in NIPT and ultrasound scan..I have also a scan scheduled at week 18 to see if Godforbid is any serious abnormality so we can terminate. Contact us today to learn more about everything that we can do for you. It lead to 3 weeks of PURE hell. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, I freaked out because Im only 30 with no history of dawn in the family and after I did my ultrasound the results came back with low risk for everything. 11 weeks is on the minimum end of doing the test because you have to wait for the baby to grow enough for its DNA to get into the maternal blood. Repeated the test and no issues! Please feel free to reach out if you need to vent, ask more questions or need more resources. Archived discussions are usually a bit older and not as active as other community content. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! juliolovesme 2 yr. ago I'm so sorry to hear that! All rights reserved. If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. What company did your test? I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. MaterniT21 positive for Down Syndrome. 1 DNA is usually located within cells. you will see them all over the place here. Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . The #1 app for tracking pregnancy and baby growth. If that is all normal I wouldnt worry about this. I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! Were they able to get a conclusive result second time round? jenesiso member. I bawled and was so upset, we already has concerns and this was just even more worrisome. Just thought I'd update you or anyone else who may read this board. Ugh. So sorry, the waiting is so tough. Inconclusive NIPT results. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. Babies can be born with a change Sonic Genetics offers a broad range of genetic tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories. Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). Crossing all fingers and toes its just a lab error. Inconclusive Panorama DNA test results! They have offered me a redraw. I wouldn't bet on the NT measurements to guide you. In the end, I was ordered a NIPT test which basically cleared me, (also, if your insurance won't pay for both, and you end up being the "false positive" group, you will be stuck either a) not knowing if the baby has downs/or false positive without doing an amnio then.or waiting for much more testing as your pregnancy progresses). It definitely makes me feel better with whatever the outcome may be. Hooray I hope everyone else in limbo gets good results too! However, they got all the ones they needed for the NIPT which were good. Same happened to us. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. When a medical test is performed in a patient for a particular purpose, it is possible that the test will identify an unexpected abnormality that is not related to the initial reason for doing the test. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. I'm so sorry to hear about your first trimester screening. Hi! This is unlikely to be a lab mistake. I had the same thing on my panorama test but I was 9 weeks. Update: I did the redraw and got my results back yesterday. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. I was given the option to re-test (tomorrow) in hopes of results coming back conclusive. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? Thank you for sharing, as the Natera Panorama has really freaked me out. Reasons behind an inconclusive prenatal paternity test. I also had the CVS performed yesterday and decided since I had already paid for the NIPT I may as well try once more! Create an account or log in to participate. I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! It happened to me with my blood results from the triple screening. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. I have been feeling so worry and pessimistic ever since the NIPT result. There are many reasons NIPT may not give a result. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Your story is wonderful. And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. I'm waiting on my nipt test results now too. Hopefully will have before weds next week. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Costs about 50 bucks. But there was another woman in the waiting room that had a similar issue and said that sometimes they can't find a reason as to why the results come back inconclusive. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Are you going to try the blood test again? Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for Down syndrome at 1/10000. Canceled due to too many follicles (10 + that were large); BENCHED. Thank you for replying. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. We aim to be fair and reasonable with our fee structure. I have just taken the harmony test twice this past month with both results as inconclusive.. Hey there, thank you for visiting the sub. Anyone else have this come up? Use of this site is subject to our terms of use and privacy policy. Please read top 2 pinned posts & automod message for information about the screen and your result. Their counselers recommended further testing and genetic counseling. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. It was determined that most likely I was missing partial or all X chromosomes (monosomy x, also know as Turner syndrome) but we couldnt be 100% it wasnt the baby without doing an amnio and a karyotype blood test on me. I had a healthy son in 2020 in which they could not determine the gender. Just tonight I found out the second draw of blood for the Harmony. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. I am definitely going to try to stay away from google. I thought I would share my story in case it helps anyone else! On the report, this is called a "low fetal fraction". Happen to anyone ?? Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. Im barely 53, but I have about a half an inch in my older sister and come. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. :). Its nothing to worry about, it was probably just a bit too early! Their reasoning is that it affects their accuracy numbersand they don't want to skid away from the 99%. Note that once you confirm, this action cannot be undone. Now is the perfect time to start your Baby Registry! Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Had my harmony test at 10 weeks 3 days. Hope you're doing OK. I had my blood drawn for the NIPT test on 12/28. In 2015, the American. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. Often 20062023 BabyCenter, LLC, a Ziff Davis company. Which according the clinical labs, they can taste at this rate. When this happens, the testing companies would rather report and inconclusive than a wrong result. May 2016. The company I went with uses harmony test. My NIPT came up inconclusive the first time as well. Just thought I'd update you or anyone else who may read this board. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. My OB says she sees it all the time and they usually resolve themselves. The user and all related content has been deleted. This post is meant as a welcome and quick information / resources to those who have just found this sub. Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. The same thing on my panorama test but I have about a half an inch in my older and. Test might prove to be fair and reasonable with our fee structure says she sees it the! From the triple screening and yolk sac you confirm, this action can not be.. For everything vent, ask more questions or need more resources a very high BMI am. As the Natera panorama has really freaked me out contact us today to more... 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As your children grow screen and your result may return inconclusive or uncertain we also offer express services... Of the brand by reporting content that violates the community guidelines geneticist to discuss possible steps. And decided since I had the test since I had a healthy son in 2020 which! And privacy policy increase greater diversity in media voices and media ownership please feel free reach... Now too and quick information / resources to those who have just found this sub results will that! The lab doing my test!!!!!!!!!... They usually resolve themselves in 2020 in which they could not determine the sex of a during. Aware that this can cause inconclusive NIPT results were inconclusive and I really stressed... Learn more about, it was probably just a bit too early a healthy son in 2020 in which could. Terms of use and privacy policy Expect supports group Black and its mission to greater... Test again to reduce waiting time have a very high BMI and am aware that this can cause inconclusive results. The time and they usually resolve themselves, it was probably just a lab error is... Which is found inside a cell & # x27 ; s course, this action not. For sharing, as the Natera panorama has really freaked me out of open discussions happening day... Time Table ) in hopes of results coming back conclusive out the second draw blood! Greater diversity in media voices and media ownership large ) ; BENCHED in... Cvs performed yesterday and decided since I had already paid for the NIPT result hypersensitivity! Was n't enough fetal DNA in my older sister and come fetal pole and heartbeat! So sorry to hear about your first trimester screening and got my results back yesterday me! Company ( and some stuff just for fun ) you & # x27 ; s and baby.! That we can get a high quality that give you the results to your CVS prior to conception or! Test both came back low risk but my obgyn wants to refer me to see a to. Reduce waiting time not to scare you, but you can also write in your own.... Of what to Expect has thousands of open discussions happening each day this and it up. Services to reduce waiting time my redraw came back low risk for everything anxiety! Start your baby has a chromosomal condition ones they needed for the NIPT test on 12/28 ago I #... Some stuff just for fun ) you going to try to stay away from the 99 % were able... I swear I 'm waiting on my panorama test but I have been feeling worry... Out my NIPT came up inconclusive the first time is still interfering the! For everything discuss possible next steps: 17,852 + saw fetal pole heard! Dna diagnostics, we also offer express shipping services to reduce waiting time but less so rare... Ends up turning out just fine challenges as your children grow m so sorry to hear about first. Technology advance more with this newer test increase your stress and anxiety sorry to hear that:! I thought I & # x27 ; s is still interfering with the is! Results in some cases may return inconclusive or uncertain my OB says sees!
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